Pathophysiology of Disease: An Introduction to Clinical Medicine


  Pathophysiology of Disease: An Introduction to Clinical Medicine


Goal and Audience

The goal of Pathophysiology of Disease: An Introduction to Clinical Medicine, as outlined in the introductory chapter (Chapter 1), is to introduce students to clinical medicine by reviewing the pathophysiologic basis of the symptoms and signs of various common diseases
. The book has proved useful as a text for both Pathophysiology and Introduction to Clinical Medicine courses in medical schools, and it has been popular in similar courses in nursing schools, physician assistants’ training programs, and other allied health programs
. It is valuable to students early in their medical school years by highlighting the clinical relevance of their basic science courses, and in preparation for their USMLE Step 1 examinations
. The book is also helpful to students engaged in their internal medicine and surgery clerkships, and to house officers as an up-to-date summary of relevant physiology and a source of key references
. Practitioners (both general internists and specialists who provide generalist care) will find it beneficial as a refresher text, designed to update their knowledge of the mechanisms underlying 132 commonly encountered diseases and disorders. Nurses, nurse-practitioners, physician assistants, and other allied health practitioners have found that its concise format and broad scope facilitate their understanding of these basic disease entities. Pathophysiology of Disease has been widely adopted in the United States, Canada, and the United Kingdom, and it has been translated into Spanish, Italian, Chinese, Japanese, Greek, and Turkish
. Both the text and its Case Study Questions and Answers are also available online at, the online version of McGraw-Hill’s many medical textbooks (search under “Books, Library, Basic Science” for “Pathophysiology,” listed alphabetically). 

New Features for This Edition

In preparation for this eighth edition, the editors and authors reviewed the entire book
. There have been many text revisions aimed at updating information, improving clarity, and eliminating minor errors. With emphasis on recent pertinent reviews, references have been entirely updated, as have figures and tables. “Checkpoints,” collections of review questions, continue to appear throughout the chapters and have been revised.

Examples of Substantive New Content Found in This Eighth Edition 

• Update on components and physiology of normal immunity 
• Most recent surveillance case definition for HIV infection 
• Explication of the concepts of innate immunity and pathogen-associated molecular patterns 
• Totally revised chapter on neoplasia, including 19 new figures and 4 new tables 
• New figure illustrating iron transport and regulation in the duodenal enterocyte 
• New chapter section on urticaria (perivascular dermatitis) • New chapter section on various forms of spinocerebellar ataxia • Clarification in text and figures of regional alterations in the overall distribution of ventilation and perfusion referred to as mismatch, including concepts of anatomic versus alveolar (wasted ventilation) dead space and right-to-left shunt 
• Update on genetic factors implicated in asthma risk, as well as allergic versus nonallergic asthma 
• Newly rewritten section on idiopathic pulmonary fibrosis as a prototypic restrictive (interstitial) lung disease
• Extensive revision of sections on pulmonary edema, adult respiratory distress syndrome (ARDS), and pulmonary venous thromboembolism 
• Expanded material on paragangliomas 
• New figures on mechanisms leading to nonalcoholic fatty liver disease and to hepatic steatosis 
• New table summarizing adverse prognostic signs in acute pancreatitis derived from the Acute Pancreatitis Classification Working Group’s 2012 classification, a revision of the Atlanta international consensus classification and definitions of acute pancreatitis 
• New table summarizing genetic syndromes associated with . .pancreatic cancer


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