Basic and Clinical Pharmacology 12/E

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The twelfth edition of Basic & Clinical Pharmacology continues
the important changes inaugurated in the eleventh edition, with
extensive use of full-color illustrations and expanded coverage of
transporters, pharmacogenomics, and new drugs. Case studies
have been added to several chapters and answers to questions
posed in the case studies now appear at the end of each chapter.
As in prior editions, the book is designed to provide a comprehensive, authoritative, and readable pharmacology textbook for
students in the health sciences. Frequent revision is necessary to
keep pace with the rapid changes in pharmacology and therapeutics; the 2–3 year revision cycle of the printed text is among the
shortest in the field and the availability of an online version provides even greater currency. In addition to the full-color illustrations, other new features have been introduced. The Case Study
Answer section at the end of chapters will make the learning process even more interesting and efficient. The book also offers
special features that make it a useful reference for house officers
and practicing clinicians.
Information is organized according to the sequence used in
many pharmacology courses and in integrated curricula: basic
principles; autonomic drugs; cardiovascular-renal drugs; drugs with
important actions on smooth muscle; central nervous system
drugs; drugs used to treat inflammation, gout, and diseases of the
blood; endocrine drugs; chemotherapeutic drugs; toxicology; and
special topics. This sequence builds new information on a foundation of information already assimilated. For example, early presentation of autonomic nervous system pharmacology allows students
to integrate the physiology and neuroscience they have learned
elsewhere with the pharmacology they are learning and prepares
them to understand the autonomic effects of other drugs. This is
especially important for the cardiovascular and central nervous
system drug groups. However, chapters can be used equally well in
courses and curricula that present these topics in a different
Within each chapter, emphasis is placed on discussion of drug
groups and prototypes rather than offering repetitive detail about
individual drugs. Selection of the subject matter and the order of
its presentation are based on the accumulated experience of teaching this material to thousands of medical, pharmacy, dental,
podiatry, nursing, and other health science students.
Major features that make this book particularly useful in integrated curricula include sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their
effects—in other words, clinical pharmacology is an integral part of
this text. Lists of the commercial preparations available, including

trade and generic names and dosage formulations, are provided at
the end of each chapter for easy reference by the house officer or
practitioner writing a chart order or prescription.

Significant revisions in this edition include:

In addition to the Case Studies used to open many chapters,
Case Study Answers at the end of these chapters provide an
introduction to the clinical applications of the drugs discussed.
• A Drug Summary Table is placed at the conclusion of most
chapters; these provide a concise recapitulation of the most
important drugs.
• Many new illustrations in full color provide significantly more
information about drug mechanisms and effects and help to
clarify important concepts.
• Major revisions of the chapters on sympathomimetic, sympathoplegic, antipsychotic, antidepressant, antidiabetic, antiinflammatory, and antiviral drugs, prostaglandins, nitric
oxide, hypothalamic and pituitary hormones, and immunopharmacology.
• Continued expansion of the coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and
drug transporters.
• Descriptions of important new drugs released through August
An important related educational resource is Katzung &
Trevor’s Pharmacology: Examination & Board Review, ninth edition
(Trevor AJ, Katzung BG, & Masters SB: McGraw-Hill, 2010).
This book provides a succinct review of pharmacology with over
one thousand sample examination questions and answers. It is
especially helpful to students preparing for board-type examinations. A more highly condensed source of information suitable
for review purposes is USMLE Road Map: Pharmacology, second
edition (Katzung BG, Trevor AJ: McGraw-Hill, 2006).
This edition marks the 30th year of publication of Basic &
Clinical Pharmacology. The widespread adoption of the first eleven
editions indicates that this book fills an important need. We
believe that the twelfth edition will satisfy this need even more
successfully. Spanish, Portuguese, Italian, French, Indonesian,
Japanese, Korean, and Turkish translations are available.
Translations into other languages are under way; the publisher
may be contacted for further information.
I wish to acknowledge the prior and continuing efforts of my
contributing authors and the major contributions of the staff at
Lange Medical Publications, Appleton & Lange, and McGraw-Hill,
vii and of our editors for this edition, Donna Frassetto and Rachel
D’Annucci Henriquez. I also wish to thank my wife, Alice Camp,
for her expert proofreading contributions since the first edition.
This edition is dedicated to the memory of James Ransom,
PhD, the long-time Senior Editor at Lange Medical Publications,
who provided major inspiration and invaluable guidance through
the first eight editions of the book. Without him, this book would
not exist.
Suggestions and comments about Basic & Clinical Pharmacology
are always welcome. They may be sent to me in care of the


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