Essentials of Medical Physiology 8E 2019 pdf

    Download Essentials of Medical Physiology 8E 2019 pdf Easily In Format For Free


Vedprakash Mishra Dr BC Roy National Awardee DSc (Honoris Causa) by four Universities and DMSc (Honoris Causa) Professor Emeritus Chancellor, Krishna Institute of Medical Sciences, Karad, Maharashtra, India

  Pages:  2691

  •  Language: English   
  •  Format: PDF           
  •   Size: 103  MB   

Section 1 – General Physiology

1. Cell 2. Cell Junctions 3. Transport Through Cell Membrane 4. Homeostasis

Section 2 – Blood and Body Fluids

5. Body Fluids 6. Blood 7. Plasma Proteins 8. Red Blood Cells 9. Erythropoiesis 10. Hemoglobin and Iron Metabolism 11. Erythrocyte Sedimentation Rate, Packed Cell Volume and Blood Indices 12. Anemia 13. Hemolysis and Fragility of Red Blood Cells 14. White Blood Cells 15. Immunity 16. Platelets 17. Hemostasis 18. Coagulation of Blood 19. Blood Groups 20. Blood Transfusion 21. Blood Volume 22. Reticuloendothelial System and Tissue Macrophage 23. Spleen 24. Lymphatic System and Lymph 25. Tissue Fluid and Edema

Section 3 – Muscle Physiology

26. Classification of Muscles 27. Structure of Skeletal Muscle 28. Properties of Skeletal Muscle 29. Changes During Muscular Contraction 30. Neuromuscular Junction 31. Smooth Muscle 32. Electromyogram and Disorders of Skeletal Muscle 33. Endurance of Muscle

Section 4 – Digestive System

34. Overview of Digestive System 
35. Salivary Secretion 
36. Gastric Secretion 
37. Pancreatic Secretion 
 38. Liver and Biliary System 
39. Functions and Secretions of Small Intestine 
40. Functions and Secretions of Large Intestine 
41. Movements of Gastrointestinal Tract
42. Gastrointestinal Hormones 
43. Digestion, Absorption and Metabolism of Carbohydrates 
44. Digestion, Absorption and Metabolism of Proteins 
45. Digestion, Absorption and Metabolism of Lipids 

Section 5 – Renal Physiology and Skin
46. Overview of Kidney 
47. Nephron 
48. Juxtaglomerular Apparatus 
49. Renal Circulation 50. Urine Formation 
51. Concentration of Urine 
52. Acid-base Balance 
53. Acidification of Urine and Role of Kidney in Acid-base Balance 
54. Renal Function Tests 
55. Renal Failure 
56. Micturition 
57. Dialysis and Artificial Kidney 
58. Diuretics 
59. Skin 
60. Body Temperature

Section 6 – Endocrinology 

61. Overview of Endocrine System 
62. Hormones 
63. Pituitary Gland 
64. Thyroid Gland 
65. Parathyroid Glands and Physiology of Bone 
66. Endocrine Functions of Pancreas 
67. Adrenal Cortex 
68. Adrenal Medulla 
69. Endocrine Functions of Other Organs 
70. Local Hormones

Section 7 – Reproductive System 

71. Male Reproductive System 
72. Seminal Vesicles 
73. Prostate Gland 
74. Semen 
75. Female Reproductive System 
76. Ovary 
77. Menstrual Cycle 
78. Ovulation 
79. Menopause
80. Fertility and Infertility 
81. Pregnancy and Parturition 
82. Placenta 
83. Pregnancy Tests 
84. Mammary Glands and Lactation 
85. Fertility Control

Section 8 – Cardiovascular System 

86. Overview of Cardiovascular System 
87. Properties of Cardiac Muscle 
88. Cardiac Cycle 
89. Heart Sounds 
90. Cardiac Murmur 
91. Electrocardiogram 
92. Vector
93. Arrhythmia 
94. Effect of Changes in Electrolyte Concentration on Heart 
95. Cardiac Output 
96. Heart-lung Preparation 
97. Cardiac Function Curves 
98. Heart Rate 99. Hemodynamics 
100. Arterial Blood Pressure 
101. Venous Blood Pressure 
102. Capillary Blood Pressure  
103. Arterial Pulse 
104. Venous Pulse 
105. Coronary Circulation 
106. Cerebral Circulation 
107. Splanchnic Circulation 
108. Capillary Circulation 
109. Circulation Through Skeletal Muscle 
110. Cutaneous Circulation 
111. Fetal Circulation and Respiration 
112. Hemorrhage 
113. Circulatory Shock and Heart Failure 
114. Exercise, Yoga and Meditation

Section 9 – Respiratory System and Environmental Physiology

115. Overview of Respiratory System 
116. Pulmonary Circulation 
117. Mechanics of Respiration
118. Pulmonary Function Tests 
119. Ventilation and Dead Space 
120. Inspired Air, Alveolar Air and Expired Air 
121. Exchange of Respiratory Gases 
122. Transport of Respiratory Gases 
123. Regulation of Respiration 
124. Diseases and Disorders of Respiration 
125. High Altitude and Space Physiology 
126. Deep Sea Physiology 
127. Effects of Exposure to Cold and Heat 
128. Artificial Respiration 
129. Effects of Exercise on Respiration

Section 10 – Nervous System
130. Overview of Nervous System 
131. Neuron 
132. Classification of Nerve Fibers 
133. Properties of Nerve Fibers 
134. Degeneration and Regeneration of Nerve Fibers 
135. Neuroglia 
136. Receptors 
137. Synapse 
138. Neurotransmitters and Neuromodulators 
139. Reflex Activity 
140. Spinal Cord 
141. Somatosensory System and Somatomotor System 
142. Physiology of Pain 
143. Brainstem 
144. Thalamus 
145. Internal Capsule 
146. Hypothalamus 
147. Cerebellum 
148. Basal Ganglia 
149. Cerebral Cortex 
150. Limbic System 
151. Reticular Formation 
152. Preparations of Animals for Experimental Studies 
153. Proprioceptors 
154. Maintenance of Posture and Equilibrium 
155. Vestibular Apparatus
156. Electroencephalogram 
157. Physiology of Sleep 
158. Epilepsy 
159. Higher Intellectual Functions 
160. Cerebrospinal Fluid 
161. Autonomic Nervous System

Section 11 – Special Senses 

162. Eye 
163. Visual Process 
164. Field of Vision 
165. Visual Pathway 
166. Pupillary Reflexes 
167. Color Vision 
168. Refractive Errors 
169. Ear 
170. Auditory Pathway
171. Mechanism of Hearing 
172. Auditory Defects 
173. Sensation of Taste 
174. Sensation of Smell


Two decades have passed since the first edition of Essentials of Medical Physiology was published in 1999. Now we are glad to bring out its Eighth Edition. This edition strives to keep the core subject matter in physiology up-to-date. We are humbled by the popularity and success that the book has achieved. We would like to thank the students, faculty, doctors and health professionals around the world for their support, feedback and appreciation without which we could not have made it where we are now. The book has come a long way since its first edition. It would not have been possible to bring the book to this level without efforts and hard work of my wife Dr Prema Sembulingam and also coauthor of this book. 

Her encouragement, emotional and professional support have been a driving force for me. Though we miss her now, the efforts and work rendered by her for this edition also could not be forgotten. That made me to mention “We” in this preface also. We have made some changes in this edition based on our study and suggestions from our colleagues and fellow teachers from various institutes and universities of India and abroad. Many tables and boxes have been added for more clarity and detail. The book has been updated with recent findings in physiology and more pathophysiological facts in accordance with modern curriculum of medical education.

 We would like to thank the publishers for their enthusiasm and support. They worked with us to make the new edition appealing, easy to browse with rich format and pleasant coloring. As always, we welcome and appreciate your opinions, feedback, comments and suggestions. This has and will help us improve the quality of the book and its contents.
The need for having a simple book with basic principles of medical physiology has been felt since long. A sincere and maiden attempt has been made with the idea of fulfilling the requirements of present-day curriculum. The script of the book is formatted in such a way that it will be suitable not only for medical students but also for dental students and the students of allied health subjects, like Physiotherapy, Occupational Therapy, Pharmacy, Nursing, Speech, Hearing and Language, etc.

Written in a textbook form, this book encompasses the knowledge of the basic principles of physiology in each system. An attempt is also made to describe the applied physiology in each system. To give an idea of the matter to be studied, the topics are listed at the beginning of each chapter. Most of the figures are given in a schematic form to enable the students understand and reproduce the facts. The probable questions given for each section will help the students preparing for their examinations. However, it will be ideal for the students to read each section thoroughly before referring to the questions. We will be very happy to receive opinions, comments and valuable suggestions from all our senior colleagues, fellow teachers and students, so that every aspect of the book can be reviewed in the succeeding editions. 


Physiology is the most fascinating and ancient branch of science. It is fascinating because it unfolds the mystery of the complicated functional aspects of the individual organs in the body. It is ancient because it exists ever since the origin of life. Even before knowing the language, culture and society, man knew about hunger, thirst, pain and fear, which are the basics of physiology. Physiology is defined as the study of functions of various systems and different organs of the body. Physiology is of different types, namely Human Physiology, Animal Physiology and Plant Physiology. Human Physiology and Animal Physiology are very much inter-related. Knowledge of Human Physiology is essential to understand the other allied subjects, like Biochemistry, Pharmacology, Pathology, Medicine, etc. However, it is worthwhile to have a brief knowledge of anatomy of different systems and various organs to understand the principles of Human Physiology. The basic physiological functions include provision of oxygen and nutrients, removal of metabolites and other waste products, maintenance of blood pressure and body temperature, hunger and thirst, locomotor functions, special sensory functions, reproduction and the higher intellectual functions, like learning and memory. In the unicellular organisms, all the physiological functions are carried out by simple diffusion through the cell membrane. Because of the evolutionary and ecological changes over the years, an individual system is developed for each function, such as digestive system, cardiovascular system, respiratory system, excretory system, etc. Every system in the body is independent structurally and functionally; yet all the systems are interdependent. Human Physiology is usually studied under the following 


1. General Physiology 
2. Blood and Body Fluids 
3. Muscle Physiology 
4. Digestive System 
5. Renal Physiology and Skin 
6. Endocrinology 
7. Reproductive System 
8. Cardiovascular System 
9. Respiratory System and Environmental Physiology 
10. Nervous System 
11. Special Senses


Font Size
lines height