Volpe's Neurology of the Newborn, Seventh Edition 2024
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EDITOR-IN-CHIEF
JOSEPH J. VOLPE, MD
Neurologist-in-Chief Emeritus
Department of Neurology
Boston Children’s Hospital
Bronson Crothers Distinguished Professor of Neurology
Harvard Medical School
Boston, Massachusetts
Lead Associate Editor
TERRIE E. INDER, MBCHB, MD
Director, Center for Neonatal Research
Department of Pediatrics
Children’s Hospital of Orange County
Orange, California
Professor
Department of Pediatrics
University of California Irvine Irvine
California
LINDA S. DE VRIES, MD, PHD
Department of Neonatology
University Medical Center Utrecht
The Netherlands Leiden
University Medical Center
LeidenThe Netherland
DONNA M. FERRIERO, MD, MS
Distinguished Professor
Department of Neurology and Pediatrics
University of California
San Francisco, California
Associate Editors
BASIL T. DARRAS, MD
Associate Neurologist-in-Chief
Department of Neurology
Boston Children´s Hospital
Joseph J. Volpe Professor of Neurology
Department of Neurology
Harvard Medical School
Boston, Massachusetts
ADRÉ J. DU PLESSIS,
MBCHB, MPH
Director, Prenatal Pediatrics Institute
Chief, Division of Prenatal and Transitional
Pediatrics Children´s National Hospital
Washington, DC
JEFFREY M. PERLMAN, MBCHB
Professor
Department of Pediatrics
Weill Cornell Medicine
Attending Neonatologist
New York Presbyterian Hospital
New York, New York
Pages: 1775
- Language: English
- Format: PDF
- Size : 78.0 MB
- Contents :
- . UNIT I: HUMAN BRAIN DEVELOPMENT
- . UNIT II: FETAL NEUROLOGY
- . UNIT III: NEUROLOGICAL EVALUATION
- . UNIT IV: SEIZURES
- . UNIT V: HYPOXIC-ISCHEMIC AND RELATED DISORDERS
- . UNIT VI: INTRACRANIAL HEMORRHAGE
- . UNIT VII: METABOLIC ENCEPHALOPATHIES
- . UNIT VIII: DEGENERATIVE DISORDERS
- . UNIT IX: NEUROMUSCULAR DISORDERS
- . UNIT X: INTRACRANIAL INFECTIONS
- . UNIT XI: PERINATAL TRAUMA
- . UNIT XII: INTRACRANIAL MASS LESIONS
- . UNIT XIII: DRUGS AND THE DEVELOPING NERVOUS SYSTEM
- . UNIT XIV: NEUROLOGY IN LOW RESOURCE SETTINGS
- PREFACE
- The 40 years since the publication of the first edition of this book have witnessed a remarkable evolution of the discipline of the neurology of the newborn. In 1981, when the first edition was published, in the preface I expressed a sense of a “new frontier” to be pioneered. Currently, articles on neonatal neurology are abundant in the major clinical journals in the fields of pediatrics, neurology, neonatology, perinatology, and obstetrics, among others, and in multiple scientific journals of the many neurobiological disciplines. Moreover, annual meetings of scientific societies in these fields are replete with clinical studies and clinical and basic research on the neurology of the newborn. Thus venturing into the new frontier sensed in 1981 has led to an extraordinarily exciting discipline and, perhaps most importantly, to the promise of effective interventions to prevent or ameliorate neurological disability in our neonatal patients .
- As with previous editions, this book is intended for a broad audience, from the most highly specialized neonatal physicians to those with a broader, more general perspective. This breadth of focus creates challenges in writing. We have avoided presenting a compendium of disembodied facts and, rather, have attempted to create a scaffold of principles upon which the ever-expanding corpus of relevant information is added. A particular effort has been exerted to bring the latest science into the clinical setting, with a special emphasis on translating new knowledge to the infant’s bedside .
- To facilitate the fundamental messaging throughout the book, we have made liberal use of tables and boxes to synthesize major points. The great illustrative value of figures, in the form of flow diagrams, key experimental findings, clinical and pathological specimens, and all types of state-of-the-art neuroimaging, is emphasized in every chapter. Approximately 1000 figures are presented in this edition. The explosion of new knowledge from the study of the newborn is reflected in the citation of more than 17,000 references. Although they are numbered consecutively in the text, the reference list in the print edition contains only the most recent citations, but all are contained in the list in the online edition .
- The organization of the book is similar to that of the sixth edition, but with an addition of five chapters, for a total of 43. The chapters are presented in 14 units. Unit I contains eight chapters that address human brain development and the disorders that present when this development is disturbed. Molecular genetics, advanced imaging, and modern-day neuropathological and neuroembryological studies have greatly advanced this area. Unit II, new to this edition, contains three chapters that address fetal neurology and illustrate the importance of understanding and investigating the maternal-fetal origins of neonatal disease. The third unit, concerning the neurological evaluation, describes new methodologies to study the newborn brain, including advanced magnetic resonance imaging (MRI) techniques. A new chapter on neurodevelopmental follow-up has been added to this unit. The fourth unit focuses entirely on neonatal seizures and has been expanded significantly. This unit serves as an effective bridge to the subsequent disease-focused units .
- Unit V, the largest in the book, consists of 10 chapters and addresses the critical area of hypoxic-ischemic and related disorders, especially those involving systemic/neuroinflammation. Each of these chapters has been updated and revised accordingly. A new chapter on inflammation has been added to this unit. Unit VI addresses intracranial hemorrhage and involves three chapters. Major advances in the study of intraventricular hemorrhage, posthemorrhagic hydrocephalus, cerebellar hemorrhage, and new MRI-delineated lesions (for example, subpial hemorrhage) are emphasized. Unit VII addresses metabolic encephalopathies, involving particularly glucose, bilirubin, and amino acid and organic acid metabolism. New insights into molecular genetics, pathogenetic mechanisms, and management are highlighted. Unit VIII comprises a single chapter on degenerative disorders. Emphasis is placed on major insights provided by molecular genetics and advances in therapies. Unit IX addresses neuromuscular disorders. The four chapters in this unit are notably comprehensive and emphasize recent advances in diagnosis by molecular genetics and in treatment. Unit X on intracranial infections includes chapters on viral, protozoan, and related intracranial infections and on bacterial and fungal infections. These two chapters have been greatly expanded. Unit XI focuses on perinatal trauma and a wide variety of injuries involving intracranial structures, the spinal cord, and peripheral nerves.
- Unit XII addresses intracranial mass lesions, especially brain tumors and vein of Galen malformations. Especially emphasized are new insights into molecular characterization of brain tumors and the relation of this characterization to management and outcomes. Advances in diagnosis and management of vein of Galen malformations are presented. Unit XIII is a single chapter on drugs and the developing nervous system. Recent insights into the spectrum of drugs involved, the related prenatal and postnatal syndromes, and optimal management are described in this appreciably expanded chapter. The final unit contains a new chapter that illustrates the disappointing gap in resources available in low-resource settings and the resulting adverse effects on incidence of injuries and outcomes .
- I am privileged to be joined by a distinguished group of authors, most of whom are longtime colleagues. Among them are co-editor Terrie Inder and associate editors Basil Darras, Linda de Vries, Adré du Plessis, Donna Ferriero, and Jeffrey Perlman, who are leaders in their respective fields. New to this edition are Robin Haynes, Peter Anderson, Alistair Gunn, Pierre Gressens, Michael Rivkin, Jane Harding, Jon Watchko, Gerard Berry, and Mohamed El-Dib. Terrie Inder, an active investigator and leader of a major neonatology program at Children’s Hospital of Orange County (University of California Irvine), deserves particular recognition. In addition to authoring or coauthoring multiple excellent chapters in this book, she provided invaluable opinions and input on many other chapters. Additionally, she interacted with Elsevier about many issues related to the preparation of the book, many of which are far beyond my rudimentary skills in digital technology.
- We are all particularly indebted to Shaye Moore, leader of the Medical Writing Team in the Department of Neurology at Boston Children’s Hospital/Harvard Medical School. She tolerated my need to write and edit in longhand and managed thousands of references from multiple chapters and digital libraries with great facility. No challenge was ever too difficult for her to resolve. Additionally, my assistant for the past 30 years, Irene Miller, again typed and retyped multiple manuscripts and managed innumerable references with aplomb. We are especially grateful to the Elsevier team, led by Sarah Barth, who supported my pursuit of perfection with grace, skill, and understanding. We thank also Kate Mannix, who managed every detail required for generation of a superb final product. The guidance, patience, and efficiency of the entire group brought this very large project to fruition.
